Job Description

Job Title : Research Technician II

Location : South San Francisco, CA 94080 (fully on-site)

Duration : Until 11/23/2026

Interview Format : Virtual (Three rounds)



Department : Structural Biology, Protein Sciences



The opportunity

• We are seeking a motivated scientist interested in using structural biology to understand the molecular mechanisms of large macromolecular complexes involved in DNA repair processes.
• The role involves protein purification, reconstitution, and structure determination of DNA-protein complexes using cryoEM.
• Additionally, you will help to develop functional biochemical assays to assess and determine the mechanism of action of various multi-subunit protein complexes.
• You will be highly encouraged to think deeply about the biological problem, make significant intellectual contributions to the chosen research project, and work closely with other team members.
• It is an exceptional opportunity to pursue basic and drug-discovery questions in a well-resourced biotechnology environment.

Qualifications

• BS/MS degree with 3-5 years of experience or a PhD with 0-2 years of experience in Biochemistry, Chemical Biology, Structural Biology, or a related discipline.
• Hands-on experience designing and optimizing the purification of challenging protein targets (including protein complexes) for structural and/or functional studies.
• Development of functional biochemical and biophysical assays.
• Experience in cryoEM sample and grid preparation (beneficial qualification).
• Experience with mammalian cell culture functional assays (beneficial qualification)

Requirements

• The role involves Protein Purification, Reconstitution, and Structure Determination of DNA-protein complexes using cryoEM.
• To Develop functional Biochemical Assays to assess and determine the mechanism of action of various Multi-Subunit Protein complexes.
• BS/MS degree with 3-5 years of experience or a PhD with 0-2 years of experience in Biochemistry, Chemical Biology, Structural Biology.

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